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ABBV-706 Demonstrates Tumor Shrinkage, Tolerability in Pretreated R/R SCLC
Updated findings from the dose-optimization part of a first-in-human phase 1 trial (NCT05599984) showed that ABBV-706, a seizure-related homolog prote...
Evaluating the Evolution of Myelodysplastic Syndrome Diagnostic Criteria
At the Society of Hematological Oncology 2025 Annual Meeting, CancerNetwork® spoke with Sanam Loghavi, MD, following her role in a discussion titled “...
The Clinical Implications of Having a “Cure” in Multiple Myeloma
The clinical implications of defining a cure in multiple myeloma will shift the treatment landscape such that patients only require a finite number of...
Osimertinib Combo Exhibits OS Improvement in EGFR-Mutated Advanced NSCLC
Osimertinib (Tagrisso) plus chemotherapy exhibited a statistically significant and clinically meaningful overall survival (OS) improvement vs osimerti...
Perioperative Pembrolizumab Combo Improves Responses in NSCLC Subgroups
Neoadjuvant pembrolizumab (Keytruda) plus chemotherapy followed by surgery and adjuvant pembrolizumab improved various response and survival outcomes...
Pirtobrutinib Improves PFS in Treatment-Naïve CLL/SLL Without 17p Deletions
Pirtobrutinib (Jaypirca) demonstrated a highly statistically significant and clinically meaningful improvement in progression-free survival (PFS) comp...
Ivonescimab/Chemo After TKI Progression Improves PFS in EGFR-Mutated NSCLC
Ivonescimab plus carboplatin/pemetrexed elicited a significant and clinically meaningful progression-free survival (PFS) advantage vs placebo plus car...
Zidesamtinib Exhibits Durable Activity in Pretreated ROS1+ Advanced NSCLC
Zidesamtinib elicited an objective response rate (ORR) of 44% (95% CI, 34%-53%) and a complete response (CR) rate of 1% in patients with advanced ROS1...
Adjuvant Nivolumab/Chemo Reduces Recurrence Risk in Resected NSCLC
A clinically meaningful reduction in relapse rates was found with nivolumab (Opdivo)/chemotherapy vs chemotherapy alone in patients with completely re...
Concurrent Durvalumab Plus Chemo/RT Does Not Improve Efficacy in Stage III NSCLC
Efficacy was not improved with concomitant durvalumab (Imfinzi) during chemotherapy and radiation (RT) for patients with stage III unresectable non-sm...
ABBV-706 Demonstrates Tumor Shrinkage, Tolerability in Pretreated R/R SCLC
Evaluating the Evolution of Myelodysplastic Syndrome Diagnostic Criteria
The Clinical Implications of Having a “Cure” in Multiple Myeloma
Osimertinib Combo Exhibits OS Improvement in EGFR-Mutated Advanced NSCLC
Perioperative Pembrolizumab Combo Improves Responses in NSCLC Subgroups
Pirtobrutinib Improves PFS in Treatment-Naïve CLL/SLL Without 17p Deletions
Ivonescimab/Chemo After TKI Progression Improves PFS in EGFR-Mutated NSCLC
Zidesamtinib Exhibits Durable Activity in Pretreated ROS1+ Advanced NSCLC
Adjuvant Nivolumab/Chemo Reduces Recurrence Risk in Resected NSCLC
Concurrent Durvalumab Plus Chemo/RT Does Not Improve Efficacy in Stage III NSCLC
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