Gastroenterology
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Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease
McCarthy, N. et al. Distinct mesenchymal cell populations generate the essential intestinal BMP signaling gradient. Cell Stem Cell 26, 391–402.e5 (202...
Response to: ‘Perspective on enhancing CRC risk prediction’ by Zheng and Wang | Gut
Subscribe Log In More Log in via InstitutionLog in via OpenAthensLog in via BSG Log in using your username and password For personal accounts OR manag...
Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating GNLY +CD8+ T cells
ORGANOIDS COLORECTAL CANCER MICROBIOME We have recently reported the immune-promoting effects of butyrate in microsatellite stable (MSS) colorectal ca...
Critical appraisal of the HELIOS study on surveillance in IBD patients
SURVEILLANCE IBD We read with great interest the recently published study by Groen et al comparing high-definition (HD) dye-based chromoendoscopy (CE)...
Withdrawal of antitumour necrosis factor in patients with inflammatory bowel disease in remission: a randomised placebo-controlled clinical trial of GETECCU
INFLAMMATORY BOWEL DISEASE INFLIXIMAB CROHN'S DISEASE ULCERATIVE COLITIS TNF-ALPHA We read with interest Gisbert et al’s report of EXIT, a randomised...
Non-invasive tests of fibrosis in the management of MASLD: revolutionising diagnosis, progression and regression monitoring
Abstract With the recent conditional approval of resmetirom by the US Food and Drug Administration, the treatment of metabolic dysfunction-associated...
Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders
BRAIN/GUT INTERACTION INTESTINAL MICROBIOLOGY NEUROIMMUNOLOGY Key messages The gut microbiota impacts the hedonic and motivational aspects of food int...
High-protein diets alleviate tumour growth and drug resistance by promoting AKT aggregation and turnover
Contributors Conception and design: JG and LB; Development of methodology: LB, YZ, QJ and YS; Acquisition of data (provided animals or provided facili...
Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming
Introduction Epithelial cell injury is a hallmark of liver diseases, which creates an inflammatory environment, potentially allowing regenerative proc...
DNAJ-PKAc fusion heightens PLK1 inhibitor sensitivity in fibrolamellar carcinoma
Introduction Fibrolamellar carcinoma (FLC) is a life-threatening variant of liver cancer affecting adolescents and young adults.1 FLC has a dismal ove...
Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease
Response to: ‘Perspective on enhancing CRC risk prediction’ by Zheng and Wang | Gut
Critical appraisal of the HELIOS study on surveillance in IBD patients
Non-invasive tests of fibrosis in the management of MASLD: revolutionising diagnosis, progression and regression monitoring
Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders
High-protein diets alleviate tumour growth and drug resistance by promoting AKT aggregation and turnover
Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming
DNAJ-PKAc fusion heightens PLK1 inhibitor sensitivity in fibrolamellar carcinoma
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