Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2

ARTICLE: Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2 AUTHORS: Benjamin Koleske, Courtney Schill, Saranathan Rajagopalan, Somnath Shee, Yazmin B Martinez-Martinez, Manish Gupta, Jessica Shen, William R Jacobs Jr, William R Bishai JOURNAL: Sci Adv. 2025 Jul 4;11(27):eadw5194. doi: 10.1126/sciadv.adw5194. Epub 2025 Jul 2. Abstract Mycobacterium tuberculosis (M.tb) is remarkable for its immense global disease burden and low mutation rate. Despite strong selective… Read More »Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2 The post Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2 first appeared on Medicine Matters.