Special Episode: Understanding Fremanezumab's Expanded Indication in Pediatric Migraine

Advertisement Commentary|Podcasts|September 12, 2025 Special Episode: Understanding Fremanezumab's Expanded Indication in Pediatric Migraine Author(s)Marco MeglioPatricia Pozo-Rosich, MD, PhD Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Patricia Pozo-Rosich, MD, PhD. [LISTEN TIME: 19 minutes] Advertisement A special episode of the NeurologyLive® Mind Moments® podcast is now live! Scroll down to listen or click here to subscribe on your favorite streaming service.The Mind Moments® podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis (MS), Parkinson disease, dementia, sleep disorders, and more.In this special episode, "Understanding Fremanezumab's Expanded Indication in Pediatric Migraine," Patricia Pozo-Rosich, MD, PhD, head of the neurology department at Vall d’Hebron University Hospital, discussed the recent FDA approval of fremanezumab (Ajovy; Teva) for pediatric migraine prevention. As a study author on the pivotal phase 3 SPACE trial (NCT03539393)—the study that led to its expanded indication—Pozo-Rosich reflected on the significance of having a proven therapeutic option in a population where placebo responses and lack of evidence have long complicated care. She provided insights on how the trial was designed and the challenges of running pediatric studies, particularly in adolescents. Additionally, she highlighted broader implications for migraine research, including efforts to reduce placebo effects, the role of CGRP pathway inhibition in younger patients, and the future promise of emerging targets such as pituitary adenylate cyclase–activating polypeptide (PACAP) antagonists and new toxin formulations.For more of NeurologyLive's coverage of fremanezumab's expanded indication in pediatric migraine, head here: FDA Approves Fremanezumab as First Anti-CGRP Preventive Therapy for Pediatric Episodic MigrainePlease enable JavascriptEPISODE BREAKDOWN1:10 – Initial reaction to fremanezumab approval and significance for pediatric migraine care5:00 – Major clinical insights and takeaways from phase 3 SPACE trial8:00 – Neurology News Minute10:20 – Challenges in pediatric migraine trials and addressing high placebo responses13:20 – Future directions in migraine therapy, including PACAP-targeting drugs and novel approachesClick here to subscribe to the Mind Moments® podcast. Be sure to leave a rating and review for the show. Thanks for listening!REFERENCE1. FDA approves expanded indication for AJjovy (fremanezumab-vfrm), the first anti-CGRP preventive treatment for pediatric episodic migraine. News release. Teva Pharmaceuticals. August 6, 2025. Accessed September 12, 2025. https://www.tevapharm.com/news-and-media/latest-news/fda-approves-expanded-indication-for-ajovy-fremanezumab-vfrm-the-first-anti-cgrp-preventive-treatment/ NewsletterKeep your finger on the pulse of neurology—subscribe to NeurologyLive for expert interviews, new data, and breakthrough treatment updates.Subscribe Now! 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[LISTEN TIME: 19 minutes] Advertisement A special episode of the NeurologyLive® Mind Moments® podcast is now live! Scroll down to listen or click here to subscribe on your favorite streaming service.The Mind Moments® podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis (MS), Parkinson disease, dementia, sleep disorders, and more.In this special episode, "Understanding Fremanezumab's Expanded Indication in Pediatric Migraine," Patricia Pozo-Rosich, MD, PhD, head of the neurology department at Vall d’Hebron University Hospital, discussed the recent FDA approval of fremanezumab (Ajovy; Teva) for pediatric migraine prevention. As a study author on the pivotal phase 3 SPACE trial (NCT03539393)—the study that led to its expanded indication—Pozo-Rosich reflected on the significance of having a proven therapeutic option in a population where placebo responses and lack of evidence have long complicated care. She provided insights on how the trial was designed and the challenges of running pediatric studies, particularly in adolescents. Additionally, she highlighted broader implications for migraine research, including efforts to reduce placebo effects, the role of CGRP pathway inhibition in younger patients, and the future promise of emerging targets such as pituitary adenylate cyclase–activating polypeptide (PACAP) antagonists and new toxin formulations.For more of NeurologyLive's coverage of fremanezumab's expanded indication in pediatric migraine, head here: FDA Approves Fremanezumab as First Anti-CGRP Preventive Therapy for Pediatric Episodic MigrainePlease enable JavascriptEPISODE BREAKDOWN1:10 – Initial reaction to fremanezumab approval and significance for pediatric migraine care5:00 – Major clinical insights and takeaways from phase 3 SPACE trial8:00 – Neurology News Minute10:20 – Challenges in pediatric migraine trials and addressing high placebo responses13:20 – Future directions in migraine therapy, including PACAP-targeting drugs and novel approachesClick here to subscribe to the Mind Moments® podcast. Be sure to leave a rating and review for the show. Thanks for listening!REFERENCE1. FDA approves expanded indication for AJjovy (fremanezumab-vfrm), the first anti-CGRP preventive treatment for pediatric episodic migraine. News release. Teva Pharmaceuticals. August 6, 2025. Accessed September 12, 2025. https://www.tevapharm.com/news-and-media/latest-news/fda-approves-expanded-indication-for-ajovy-fremanezumab-vfrm-the-first-anti-cgrp-preventive-treatment/ NewsletterKeep your finger on the pulse of neurology—subscribe to NeurologyLive for expert interviews, new data, and breakthrough treatment updates.Subscribe Now! Advertisement Related ArticlesNeurologyLive® Friday 5 — September 12, 2025September 12th 2025Shared Decision-Making and Ethics in Complex Neurology Clinical Research: Paul Ford, PhDSeptember 12th 2025FDA Hands Complete Response Letter to SL1009 for Pyruvate Dehydrogenase Complex DeficiencySeptember 12th 2025Expanding the Alzheimer Drug Development Pipeline September 12th 2025Enhancing Gene Therapy Safety for Duchenne Through New Recommendations: Barry Byrne, MD, PhDSeptember 11th 2025Shifting Roles in Neurology Education: Insights From the 2025 AUPN Annual MeetingSeptember 11th 2025 Latest CMEMultimediaBurst CME™ Part II: The Evolving Treatment Landscape for Huntington DiseaseSamuel A. Frank, MDView moreIn-Person + Virtual EventCarolina Neuromuscular Disease SummitSeptember 27, 2025View moreVideoEvolving Perspectives in Alzheimer's Disease: Reaching an Earlier Diagnosis, Understanding Neuroinflammation, and Exploring Therapeutic AdvancesAlireza Atri, MD, PhD; Erik S. Musiek, MD, PhD; Malú Gámez Tansey, PhD View moreCase-based SimulationSimulatEd™ From Discomfort to Relief: Acute Pain Management EssentialsJeff Gudin, MDView moreMultimedia Clinical ShowCase: Developing a Personalized Treatment Plan for a Patient with Huntington’s Disease Associated ChoreaDaniel Claassen, MD, MS; Martha A. Nance, MDView moreIn-Person + Virtual EventPutting the Patient First in Acute Pain Management: The PA’s Guide to Incorporating Cutting-Edge Science into their Treatment StrategiesOctober 9, 2025View moreIn-Person Event4th Women in Neurology ConferenceOctober 24-26, 2025Register now!VideoMedical Crossfire® - Optimizing Management for Patients With Generalized Myasthenia Gravis: Focus on Complement InhibitorsJames F. Howard Jr, MD; Nicholas J. Silvestri, MD, FAAN; Neelam Goyal, MDView moreVideoMedical Crossfire®: Integrating Real-World Data to Improve Outcomes for Patients With Multiple SclerosisCarrie M. Hersh, DO, MSc, FAAN; Anna Shah, MDView moreMultimediaBurst CME™: Optimizing Migraine Management – Addressing Unmet Needs, Individualizing Care for Diverse Populations, and Utilizing CGRP Targeted AgentsJessica Ailani, MD, FAHS, FAAN; Paul G. Mathew, MD, DNBPAS, FAAN, FAHSView moreMultimediaBurst CME™: Setting the Stage – Individualizing Migraine Care for Diverse Populations Across Care SettingsJessica Ailani, MD, FAHS, FAAN; Paul G. Mathew, MD, DNBPAS, FAAN, FAHSView moreMultimediaCommunity Practice Connections™: Optimizing the Management of Tardive Dyskinesia—Addressing the Complexity of Care With Targeted TreatmentIlan Melnick, MD; Alejandro Alva, MD; Linda Trinh, DNP, PMHNP, FNP, MPHView moreMultimediaBurst CME™: Optimizing the Use of CGRP Targeted Agents for the Treatment of MigraineJessica Ailani, MD, FAHS, FAAN; Paul G. Mathew, MD, DNBPAS, FAAN, FAHSView moreMultimediaBurst CME™: The Patient Journey – Unmet Needs From Diagnosis Through Management of MigraineJessica Ailani, MD, FAHS, FAAN; Paul G. Mathew, MD, DNBPAS, FAAN, FAHSView moreMultimedia Evolving Perspectives in Alzheimer Disease : Reaching an Earlier Diagnosis, Understanding Neuroinflammation, and Exploring Therapeutic AdvancesAlireza Atri, MD, PhD; Erik S. Musiek, MD, PhD; Malú Gámez Tansey, PhDView moreVirtual EventExpert Illustrations & Commentaries™: Visualizing the Role of B Cells as Therapeutic Targets for Generalized Myasthenia GravisOctober 31, 2025View moreVideoCases and Conversations™: Applying Best Practices to Prevent Shingles in Your PracticePaul G. Auwaerter, MD, MBA; Paul P. Doghramji, MD, FAAFP; Aruna Subramanian, MDView moreVideoPatient, Provider, and Caregiver Connection™: Pediatric Myasthenia Gravis—Current Treatment and Emerging ConceptsJohn F. Brandsema, MD; Abigail N. Schwaede, MD; Samuel J. Mackenzie, MD, PhDView moreAudioMind Moments™: Optimizing Management for Patients with Generalized Myasthenia GravisJames F. Howard Jr, MDView moreVideoIdentifying and Treating CIDP in the Modern EraJeffrey A. Allen, MD; Karissa L. Gable, MDView moreVideoCases and Conversations™: Little Voices, Big Challenges – Comprehensive Care for Pediatric Spinal Muscular AtrophyJohn Brandsema, MD; Carla D. Zingariello, DOView moreVideoCases and Conversations™: Navigating the Complexities of Managing Myasthenia Gravis in Pediatric and Pregnant Patient PopulationsJohn Brandsema, MD; Neelam Goyal, MDView moreVideoA Breath of Strength: Managing Cancer Associated LEMS and Lung Cancer as OneEstelamari Rodriguez, MD, MPH; Millie Das, MD; Ruham Nasany, MDView moreVideoStriking the Right Nerve: Managing Cancer Associated LEMS in Lung Cancer PatientsAnne Chiang, MD, PhD; J. Douglas Miles, MD, PhD, FAAN; Suma Satti, MDView moreVideoPatient, Provider, and Caregiver Connection: Improving Diagnosis and Care for Adolescent Myasthenia Gravis Patients – A New FrontierAbigail N. Schwaede, MD; Emmanuelle (Noelle) Tiongson, MDView moreVideoA New Era in NMOSD Treatment: Optimizing Therapeutic Transitions and Reducing Patient BurdenShamik Bhattacharyya, MD, MS, FAAN; Mirla Avila, MD; Dean Wingerchuk, MDView moreAudioPER Podcast™: Maximizing the Multidisciplinary Care Outcomes of Patients with Amyotrophic Lateral Sclerosis (ALS)Richard Bedlack, MD, PhDView moreAudioPER Podcast™: Best Strategies for Approaching the Diagnosis of Amyotrophic Lateral Sclerosis (ALS)Terry Heiman-Patterson, MDView moreVideoPER Postgame™: Updates from ANNA in the Management of IgA NephropathyGerald Bernard Appel, MD; Ellie Kelepouris, MD, FACP, FAHAView moreVideoPatient, Provider, and Caregiver Connection: Turning a New Leaf in Acute Pain Management – How Recent Advancements Impact the Treatment ParadigmJeffrey Gudin, MD; Jeffrey Bettinger, PharmDView morePrevious slideNext slide Advertisement Advertisement Trending on NeurologyLive1Enhancing Gene Therapy Safety for Duchenne Through New Recommendations: Barry Byrne, MD, PhD2Expanding the Alzheimer Drug Development Pipeline 3FDA Hands Complete Response Letter to SL1009 for Pyruvate Dehydrogenase Complex Deficiency4Patient-Reported Study Identifies Common Symptoms and Timing During Migraine Prodrome 5Setting Realistic Expectations for Antiamyloid Therapeutics