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Vepdegestrant extends progression-free survival in ER-positive, HER2-negative breast cancer
1. In this randomized controlled trial, vepdegestrant achieved a longer progression-free survival than fulvestrant in patients with advanced ER-positi...
Ciprofloxacin is non-inferior to aminoglycoside-ciprofloxacin for bubonic plague treatment
1. In this randomized controlled trial, among patients with bubonic plague, oral ciprofloxacin monotherapy was found to be noninferior to sequential t...
Utility of long-term routine laboratory toxicity monitoring of immunomodulatory drugs in rheumatoid arthritis
1. In this retrospective cohort study involving patients with rheumatoid arthritis on disease-modifying antirheumatic drugs, long-term routine laborat...
Significant body weight reduction with cagrilintide-semaglutide therapy
1. In this randomized controlled trial, the combination cagrilintide-semaglutide (CagriSema) resulted in significantly greater body weight reduction c...
Machine learning models diagnose celiac disease at similar performance levels to pathologists
1. Jaeckle and colleagues assessed the performance of machine learning models to diagnose celiac disease based on duodenal biopsies. 2. The machine le...
Presymptomatic treatment of spinal muscular atrophy with risdiplam leads to improved functional outcomes
1. In this single-group trial, among infants predicted to develop type 1 spinal muscular atrophy (SMA) who were treated presymptomatically with risdip...
Similar outcomes between lactated Ringer’s and normal saline for hospitalized patients
1. Among randomized hospitalized patients in this trial, routine use of lactated Ringer’s (LR) solution did not reduce the risk of death or re-hospita...
Catheter ablation improves cardiovascular prognosis in patients with atrial fibrillation compared to drug therapy
1. Compared with drug therapy, catheter ablation improved cardiovascular prognosis in patients with atrial fibrillation (AF) and fewer than 3 nonmodif...
Trastuzumab deruxtecan leads to longer overall survival than ramucirumab plus paclitaxel in HER2-positive gastric cancer
1. In this randomized controlled trial, among adults with HER2-positive unresectable or metastatic gastric cancer who had previously progressed on tra...
Australian couple-based genetic screening program feasible and accepted
1. In this prospective cohort study, genetic screening among Australian reproductive couples was widely accepted and associated with low decisional re...
Vepdegestrant extends progression-free survival in ER-positive, HER2-negative breast cancer
Ciprofloxacin is non-inferior to aminoglycoside-ciprofloxacin for bubonic plague treatment
Utility of long-term routine laboratory toxicity monitoring of immunomodulatory drugs in rheumatoid arthritis
Significant body weight reduction with cagrilintide-semaglutide therapy
Machine learning models diagnose celiac disease at similar performance levels to pathologists
Presymptomatic treatment of spinal muscular atrophy with risdiplam leads to improved functional outcomes
Similar outcomes between lactated Ringer’s and normal saline for hospitalized patients
Catheter ablation improves cardiovascular prognosis in patients with atrial fibrillation compared to drug therapy
Trastuzumab deruxtecan leads to longer overall survival than ramucirumab plus paclitaxel in HER2-positive gastric cancer
Australian couple-based genetic screening program feasible and accepted
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