Oncology
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Molecular analysis of lung adenocarcinomas from the SAFIR02-Lung cohort reveals new metastasis-associated copy-number alterations including frequent mutant-specific KRAS-allelic imbalance and identifi
Background Identifying molecular alterations specific to advanced lung adenocarcinomas could provide insights into tumour progression and disseminatio...
Durvalumab Combo Enhances OS vs Chemo Alone in Treatment-Naive ES-SCLC
First-line durvalumab (Imfinzi) plus etoposide and either carboplatin or cisplatin (EP) produced a significant improvement in overall survival (OS) co...
FDA Approves Selumetinib in Pediatric Neurofibromatosis Type 1
The FDA has approved selumetinib (Koselugo) granules and capsules for the treatment of pediatric patients who are 1 or older with neurofibromatosis ty...
Rezatapopt Yields Responses Across TP53 Y220C-Mutated Solid Tumor Types
Interim results from the phase 2 pivotal portion of the phase 1/2 PYNNACLE trial (NCT04585750) demonstrated that rezatapopt (PC14586) was efficacious...
FDA Accepts Relacorilant NDA for Platinum-Resistant Ovarian Cancer
The FDA has accepted a new drug application (NDA) for relacorilant (CORT125134) as a treatment for patients with platinum-resistant ovarian cancer, ac...
Evaluating the Proximity and Impact of a Cure in Multiple Myeloma
At the Society of Hematological Oncology 2025 Annual Meeting, CancerNetwork® spoke with Sundar Jagannath, MBBS, about his presentation on potentially...
Tarlatamab Remains Safe and Effective in Extensive-Stage SCLC
Tarlatamab-dlle (Imdelltra) plus an anti-PD-1 therapy retained long-term durability in the first-line for patients with extensive-stage small cell lun...
A call for action: closing the gap on ethnic disparities in oral cavity cancer care
The incidence of oral cavity cancers (OCC) in the UK is rising. In England, oral cancer rates, including cancers of the oral cavity and oropharynx, ha...
ctDNA Surveillance Monitoring ESMO 2025 Abstract: Study Methods, Objectives, and Baseline Characteristics for GALAXY and BESPOKE CRC
Recent data presented at a major oncology conference examined the clinical utility of circulating tumor DNA (ctDNA) monitoring combined with standard...
Effective Communication is Necessary for Pathologists to Make Accurate Diagnoses
Generally, the communication in academic oncology institutions is favorable; however, when oncologists and pathologists become busy, specimens may be...
Durvalumab Combo Enhances OS vs Chemo Alone in Treatment-Naive ES-SCLC
FDA Approves Selumetinib in Pediatric Neurofibromatosis Type 1
Rezatapopt Yields Responses Across TP53 Y220C-Mutated Solid Tumor Types
FDA Accepts Relacorilant NDA for Platinum-Resistant Ovarian Cancer
Evaluating the Proximity and Impact of a Cure in Multiple Myeloma
Tarlatamab Remains Safe and Effective in Extensive-Stage SCLC
A call for action: closing the gap on ethnic disparities in oral cavity cancer care
Effective Communication is Necessary for Pathologists to Make Accurate Diagnoses
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