Oncology
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Interpreting the GALAXY and BESPOKE CRC Data: Transient ctDNA Clearance and the Risk of Recurrence
The pooled analysis explored outcomes for colorectal cancer patients who were circulating tumor DNA (ctDNA)–ctDNA-positive after surgery, achieved tra...
Frontline Aumolertinib/Chemo Yields PFS Superiority in EGFR+ NSCLC
Results from the phase 3 ACROSS 2 trial (NCT04500717) revealed that aumolertinib plus chemotherapy significantly improved progression-free survival (P...
ProSense® Cryoablation Satisfies Patients With Breast Cancer vs Alternatives
The ProSense® cryoablation system achieved the highest complete ablation rate compared with alternatives, with 95% of patients with breast cancer bein...
IDE397 Combo Displays Promising Activity in MTAP-Deletion Urothelial Cancer
The combination of the MAT2A inhibitor IDE397 and sacituzumab govitrecan-hziy (Trodelvy) displayed promising activity in a small cohort of patients wi...
Crizotinib Falls Short on DFS and OS Improvements in ALK+ NSCLC
At the IASLC 2025 World Conference on Lung Cancer (WCLC), results from the phase 3 ALCHEMIST study (NCT02194738) were presented, showing that adjuvant...
FDA Approves Gemcitabine Intravesical System in BCG-Unresponsive NMIBC
The FDA has approved gemcitabine intravesical system (Inlexzo) for patients who have Bacillus Calmette-Guérin-unresponsive, non-muscle-invasive bladde...
ABBV-706 Demonstrates Tumor Shrinkage, Tolerability in Pretreated R/R SCLC
Updated findings from the dose-optimization part of a first-in-human phase 1 trial (NCT05599984) showed that ABBV-706, a seizure-related homolog prote...
The molecular blueprint of targeted radionuclide therapy
Bodei, L., Herrmann, K., Schöder, H., Scott, A. M. & Lewis, J. S. Radiotheranostics in oncology: current challenges and emerging opportunities. Nat. R...
The impact of cancer expectations on psychological responses following a cancer signal detected result in asymptomatic multi-cancer detection (MCED) testing
We approached 53 of those who were interested and 41 were interviewed (12 had changed their mind or could not be contacted). Participant characteristi...
NEK9-mediated Wnt signalling repressor TLE3 rewires Docetaxel resistance in cancer cells by inducing pyroptosis
Background Docetaxel is the most common chemotherapy regimen for several neoplasms, including advanced OSCC (Oral Squamous Cell Carcinoma). Unfortunat...
Interpreting the GALAXY and BESPOKE CRC Data: Transient ctDNA Clearance and the Risk of Recurrence
Frontline Aumolertinib/Chemo Yields PFS Superiority in EGFR+ NSCLC
ProSense® Cryoablation Satisfies Patients With Breast Cancer vs Alternatives
IDE397 Combo Displays Promising Activity in MTAP-Deletion Urothelial Cancer
Crizotinib Falls Short on DFS and OS Improvements in ALK+ NSCLC
FDA Approves Gemcitabine Intravesical System in BCG-Unresponsive NMIBC
ABBV-706 Demonstrates Tumor Shrinkage, Tolerability in Pretreated R/R SCLC
The molecular blueprint of targeted radionuclide therapy
NEK9-mediated Wnt signalling repressor TLE3 rewires Docetaxel resistance in cancer cells by inducing pyroptosis
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